Antidepressant drugs are not always effective in treating major depression and some medications have been implicated in causing an increased number of suicides. Magnesium deficiency is known to cause disorders of the nervous system. Many people have low magnesium levels, in part because only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies. In magnesium deficiency, the nervous system's requirements for magnesium may not be met, causing damage to nerves which could manifest as depression.

Magnesium treatment is hypothesized to be effective in treating major depression resulting from intraneuronal magnesium deficits which may be induced by stress hormones, excessive dietary calcium as well as dietary deficiencies of magnesium.

Rapid recovery (less than 7 days) from major depression has been reported in patients using 125-300mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. It is important to take the proper form of supplemental magnesium so that the magnesium can be adequately absorbed while minimizing side effects such as diarrhea.

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